{"id":3397,"date":"2023-08-25T15:07:32","date_gmt":"2023-08-25T14:07:32","guid":{"rendered":"https:\/\/www.disbiosidoctor.com\/2023\/08\/25\/inflammatory-metabolites-in-the-gut-stimulate-e-coli-virulence\/"},"modified":"2025-01-31T22:20:22","modified_gmt":"2025-01-31T21:20:22","slug":"inflammatory-metabolites-in-the-gut-stimulate-e-coli-virulence","status":"publish","type":"post","link":"https:\/\/www.disbiosidoctor.com\/en\/2023\/08\/25\/inflammatory-metabolites-in-the-gut-stimulate-e-coli-virulence\/","title":{"rendered":"INFLAMMATORY METABOLITES IN THE GUT STIMULATE E.COLI VIRULENCE"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">A multi-year study on the role of E. coli bacteria in Crohn&#8217;s disease finds that intestinal inflammation releases chemicals that feed the growth of the bacteria and promote their ability to cause inflammation.<\/p>\n\n<p class=\"wp-block-paragraph\">A particular type of E. coli, called adherent and invasive E. coli (AIEC), which attaches to and invades intestinal epithelial cells and replicates in defensive white blood cells (macrophages), has been isolated from 21 to 63 per cent of patients with ileal Crohn&#8217;s disease (which affects the last tract of the small intestine), leading researchers to suspect that AIEC plays a key role in the disease process.<\/p>\n\n<ul class=\"wp-block-list\">\n<li>In this study, the research team characterised the ileal microbiome, chemical environment and culturable bacteria together with the genetic predisposition of patients with and without Crohn&#8217;s disease.<\/li>\n\n\n\n<li>Researchers have determined that inflammation creates a chemical environment that is enriched in a number of compounds (called metabolites), in particular phospholipids and amino acids, which Crohn&#8217;s-associated E.coli can selectively utilise for growth, energy, stress resistance and movement to the gut lining<\/li>\n\n\n\n<li><p>They subsequently determined that <strong>ethanolamine<\/strong> associated with phospholipids and <strong>glutamine<\/strong> accentuated the aggressive behaviour of AIEC in cultured cells<\/p><\/li>\n\n\n\n<li><p>Previous studies have identified that people with ileal Crohn&#8217;s disease have defects in genes that impair the ability of macrophages to kill AIEC. Invasive adherent E.coli is indeed resistant and its ability to survive in the inflamed gut, where other bacteria die, may even allow it to thrive within the macrophages of a Crohn&#8217;s susceptible individual<\/p><\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><p>Want to find out more about dietary strategies to balance hunger? Chat with me or visit the blog <a href=\"http:\/\/www.disbiosidoctor.com\">www.disbiosidoctor.com<\/a><\/p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A multi-year study on the role of E. coli bacteria in Crohn&#8217;s disease finds that intestinal inflammation releases chemicals that feed the growth of the bacteria and promote their ability to cause inflammation. A particular type of E. coli, called adherent and invasive E. coli (AIEC), which attaches to and invades intestinal epithelial cells and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3251,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[739],"tags":[],"class_list":["post-3397","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-inflammation"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>INFLAMMATORY METABOLITES IN THE GUT STIMULATE E.COLI VIRULENCE - Disbiosi Doctor<\/title>\n<meta name=\"description\" content=\"Disbiosi Doctor - Dr Roger Panteri, nutritional biologist, former academic researcher, expert in Microbiota and intestinal dysbiosis, collaborator of the main centers specialized in the analysis of the microbiota and functional diseases of the intestine\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.disbiosidoctor.com\/en\/2023\/08\/25\/inflammatory-metabolites-in-the-gut-stimulate-e-coli-virulence\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"INFLAMMATORY METABOLITES IN THE GUT STIMULATE E.COLI VIRULENCE - Disbiosi Doctor\" \/>\n<meta property=\"og:description\" content=\"Disbiosi Doctor - Dr Roger Panteri, nutritional biologist, former academic researcher, expert in Microbiota and intestinal dysbiosis, collaborator of the main centers specialized in the analysis of the microbiota and functional diseases of the intestine\" \/>\n<meta property=\"og:url\" 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