{"id":3400,"date":"2023-08-25T15:15:06","date_gmt":"2023-08-25T14:15:06","guid":{"rendered":"https:\/\/www.disbiosidoctor.com\/2023\/08\/25\/histamine-intolerance-usefulness-of-fecal-histamine-test\/"},"modified":"2025-01-31T22:25:13","modified_gmt":"2025-01-31T21:25:13","slug":"histamine-intolerance-usefulness-of-fecal-histamine-test","status":"publish","type":"post","link":"https:\/\/www.disbiosidoctor.com\/en\/2023\/08\/25\/histamine-intolerance-usefulness-of-fecal-histamine-test\/","title":{"rendered":"HISTAMINE INTOLERANCE: USEFULNESS OF FECAL HISTAMINE TEST"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Histamine is a biogenic amine produced and released by several cell types, including mast cells, basophils, platelets, histaminergic neurons, and enterochromaffin cells, following stimulation. When histamine accumulates in the gut, it can contribute to the symptoms of &#8220;histamine intolerance&#8221; such as digestive difficulties, dermatological reactions, flushing, redness, colitis, gastritis, headache, and tachycardia.<\/p>\n\n<p class=\"wp-block-paragraph\">Below are the main mechanisms that induce intestinal histamine accumulation:<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Proliferation of intestinal bacteria capable of producing histamine<\/strong> (Klebsiella, Hafnia, Citrobacter, Serratia, Pseudomonas) or gram-negative bacteria that through the <strong>LPS<\/strong> membrane molecule <strong>cause strong mast cell activation<\/strong><\/li>\n\n\n\n<li><strong>Diet rich in foods that contain histamine or histamine-releasing foods<\/strong> such as coffee, chocolate, bananas, strawberries, kiwi, sausages, cheese, tomatoes, spinach, nuts, legumes<\/li>\n\n\n\n<li><strong>Deficiency of DAO and HNMT, enzymes responsible for histamine degradation<\/strong>. DAO enzyme is produced in the small intestine; therefore, any damage or inflammation can reduce its production<\/li>\n\n\n\n<li><strong>Presence of &#8216;leaky gut&#8217; i.e., intestinal permeability, <\/strong>which exposes the immune system to increased stress against environmental and food allergens, toxins, bacterial components<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\">One of the tests I often propose in these cases is the <strong>fecal histamine<\/strong> test<\/p>\n\n<ul class=\"wp-block-list\">\n<li>Measures levels of histamine produced in the intestine reflecting <strong>an in situ mast cell activity and the state of intestinal inflammation<\/strong><\/li>\n\n\n\n<li><strong>It is noninvasive and can be easily repeated over time <\/strong>to monitor the effectiveness of anti-inflammatory therapy<\/li>\n\n\n\n<li>It can be combined with analysis of other relevant markers such as <strong>DAO and fecal HNMT<\/strong> and mast cell activation markers such as <strong>tryptase, chymase, fecal carboxypeptidase<\/strong><\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\">Do you have symptoms of histamine intolerance and want to find out what tests are useful for you? Chat or email me at <a href=\"mailto:info@disbiosidoctor.com\">info@disbiosidoctor.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Histamine is a biogenic amine produced and released by several cell types, including mast cells, basophils, platelets, histaminergic neurons, and enterochromaffin cells, following stimulation. When histamine accumulates in the gut, it can contribute to the symptoms of &#8220;histamine intolerance&#8221; such as digestive difficulties, dermatological reactions, flushing, redness, colitis, gastritis, headache, and tachycardia. Below are the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3253,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[741],"tags":[],"class_list":["post-3400","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-diagnostic-tests"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HISTAMINE INTOLERANCE: USEFULNESS OF FECAL HISTAMINE TEST - Disbiosi Doctor<\/title>\n<meta name=\"description\" content=\"Disbiosi Doctor - Dr Roger Panteri, nutritional biologist, former academic researcher, expert in Microbiota and intestinal dysbiosis, collaborator of the main centers specialized in the analysis of the microbiota and functional diseases of the intestine\" \/>\n<meta name=\"robots\" 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